Buruli Ulcer (BU) is a neglected, debilitating skin disease caused by infection with Mycobacterium ulcerans. After the first definite description in 1948, M. ulcerans infections have been reported from 34 countries, mainly with tropical and subtropical climates. Following a peak of 5,954 reported BU cases globally in 2004, the number of new recorded cases has been decreasing in recent years. In 2016, a total of 1,952 BU cases were reported to the World Health Organisation (WHO) from twelve different countries. Underreporting is considered likely, as BU mostly affects populations in remote areas with limited access to the formal health sector. Although transmission pathways of M. ulcerans are still unclear, infection foci are closely associated with wetlands. This is the third most common disease after tuberculosis and leprosy. Although, it is not known how people get Buruli ulcer.One possibility is that the disease is passed to humans from some insects that are found in water. While